ABSTRACT
Solid dispersion of Rosuvastatin was prepared by solvent evaporation method; PEG (Polyethylene glycol) 4000, mannitol and urea were used as carriers. Hydrotropic studies were carried out using different hydrotropic agents (sodium acetate, sodium benzoate and salicylate) and Micellar solubilization was carried out using different surfactant solutions (sodium lauryl sulphate, tween 80 and cetrimide).The solubility enhancement of Rosuvastatin by different solubilization technique was observed in decreasing order as hydrotropic solubilization > solid dispersion > micellar solubilization. It was observed that the solubility increased with the increase in the concentration of hydrotropic agents and amongst the various hydrotropic agents used the solubility was Rosuvastatin was enhanced greatest to 55 folds with sodium salicylate. This increase may be attributed due to aggregation of the hydrotropic molecules and inclusion of one of these aggregates at high concentration probably by reacting to form an associated product as a result of hydrogen bonding.
ABSTRACT
Depression is a major health problem worldwide. Human beings need to have good awareness of causes leading to depression and adopt healthy lifestyle to reduce the risks. Prevention, early detection and intervention are crucial, particularly with support from family and friends. In addition to antidepressants, there are many complementary and self-help treatments available, such as herbs, exercise, dietary supplements, spiritual enrichment, massage, acupuncture, and light therapies. The different preventive interventions and treatment therapies are discussed in this article. Most depression symptoms can be cured, with the help of healthcare professionals, family and friends.